WHAT IS PEP?


Post-Exposure Prophylaxis (PEP): A Lifesaving HIV Prevention ToolPost-Exposure Prophylaxis (PEP) is a critical intervention for preventing HIV infection after a potential exposure. It involves a 28-day course of antiretroviral medications that must be initiated within 72 hours of exposure to be effective.

What Is PEP?

PEP is a short-term treatment designed to prevent HIV infection after a potential exposure. It involves taking a combination of antiretroviral medications daily for 28 days. The treatment must begin within 72 hours of exposure to be effective. The sooner PEP is started, the better.

When Should You Consider PEP?

PEP may be appropriate if you are HIV-negative or do not know your HIV status and have had a potential exposure to HIV in the last 72 hours, such as:

  • Unprotected sex (e.g., condom failure or exposure to an HIV-positive partner)

  • Sharing needles or other injection equipment

  • Sexual assault

  • Occupational exposure (e.g., needlestick injury)

If you think you've been exposed to HIV, seek medical attention immediately. In some states, including Illinois, pharmacists can prescribe PEP.

Side Effects of PEP

Common side effects of PEP medications include:

  • Nausea

  • Fatigue

  • Headache

  • Diarrhea

These side effects are typically mild and go away after a few days. If they persist or worsen, contact your healthcare provider.

Follow-Up Testing

After completing PEP, follow-up HIV testing is essential:

  • 4–6 weeks after exposure

  • 3 months after exposure

These tests help determine if HIV infection has occurred despite PEP.

Cost and Access

PEP is typically covered by most insurance plans, including Medicaid. If you don't have insurance or need assistance with costs, healthcare providers can apply for free or low-cost PEP through medication assistance programs.

PEP Is for Emergency Use Only

PEP is for emergency use only and is not intended for regular HIV prevention. If you're at ongoing risk for HIV exposure, such as through repeated unprotected sex or sharing needles, talk to your healthcare provider about PrEP (Pre-Exposure Prophylaxis), a daily medication that can help prevent HIV infection.

📞 Need PEP Now? Contact Nexus for help finding a provider near you.

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